Description
Description
FGF-19 is a member of the fibroblast growth factor (FGF) family. After being secreted from the intestine, FGF19 can enter the liver with the circulation and bind to FGFR4 in the liver to act. It has a hormone-like effect and plays an important role in metabolic regulation, such as regulating bile acid metabolism, regulating gallbladder filling, and improving blood glucose. Notably, aberrant expression of FGF19/FGFR4 promotes HCC development and metastasis.
Product information
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Synonyms |
FGF19;Fibroblast growth factor 19 |
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Uniprot No. |
O95750 |
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Source |
Recombinant Human FGF-19 Protein is expressed from HEK293 Cells with Flag tag at the N-terminal. It contains Leu 25-Lys 216. |
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Molecular Weight |
The protein has a predicted MW of 23.36 kDa. And it migrates as 25-30 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
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Purity |
> 95% as determined by SDS-PAGE. |
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Endotoxin |
<0.1 EU per 1μg of the protein by the LAL method. |
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Formulation |
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). |
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Reconstitution |
Centrifuge tubes before opening. Dissolve lyophilized protein with sterile PBS to ensure the concentration is greater than 100 ug/mL. |
Storage
The product should be stored at -25~-15℃ for 1 year from date of receipt.
2-7 days, 2 ~8 °C under sterile conditions after reconstitution.
3 months, -25~-15℃ under sterile conditions after reconstitution.
Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.
Notes
1.Please operate with lab coats and disposable gloves,for your safety.
2.This product is for research use only.